## Abstract The completion of the human genome sequence and the development of new techniques, which allow the visualisation of comprehensive gene expression patterns, has led to the identification of a large number of gene products differentially expressed in tumours and corresponding normal tissu
New p53-based anti-cancer therapeutic strategies
β Scribed by Klas G Wiman
- Publisher
- Springer US
- Year
- 1998
- Tongue
- English
- Weight
- 738 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1357-0560
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Limited options are available for patients with advanced stage head and neck cancer. The p53 gene is known as the βguardian of the genome.β Mutations of the p53 gene predispose to carcinogenesis. The p53 mutations are common in head and neck cancer. Replacement of p53 gene function in p
Although cancer arises from a combination of mutations in oncogenes and tumour suppressor genes, the extent to which tumour suppressor gene loss is required for maintaining established tumours is poorly understood. p53 is an important tumour suppressor that acts to restrict proliferation in response