Selection of a new generation of orally
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G. J. Kontoghiorghes; J. Barr; P. Nortey; L. Sheppard
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Article
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1993
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John Wiley and Sons
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English
β 909 KB
The prospect of selecting oral a-ketohydroxypyrldine chelators Intended for clinical use in iron overload has been examined using several animal models of efficacy and toxicity. Studies using iron dextran-loaded mice labelled with 50Fe have shown that only the 1-substituted methyl, ethyl, (n)propyl,