✦ LIBER ✦
New Non-Contiguous Polypropionates from Marine Molluscs: A Comment on their Natural Product Status
✍ Scribed by Douglas J. Brecknell; Lynne A. Collett; Michael T. Davies-Coleman; Mary J. Garson; David D. Jones
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 211 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0040-4020
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✦ Synopsis
The structure of the rearranged polypropionate ester siserrone A (8), isolated from Siphonaria serrata, was investigated by standard spectroscopic methods and the relative stereochemistry determined by ROESY spectroscopy and chemical degradation studies. Base-catalysed rearrangement of denticulatin A (13) yields the polypropionate ester ( 16) while careful work-up of S. baconi yields the siphonarins, but not the baconipyrones, as earlier reported. The natural product status of polypropionate ester metabolites is discussed.