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New Nitrogen-Containing Sesquiterpenoids from the Taiwanese Soft Coral Cespitularia taeniataMay

โœ Scribed by Yuan-Bin Cheng; Ching-Yeu Chen; Yao-Haur Kuo; Ya-Ching Shen

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
195 KB
Volume
6
Category
Article
ISSN
1612-1872

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โœฆ Synopsis

Abstract

Chemical investigation of the EtOH extract of the soft coral Cespitularia taeniata May collected in Taiwan has resulted in the isolation of two new sesquiterpene lactams, taenialactams A and B (1 and 2, resp.), and a new sesquiterpene lactone, taenialactone A (3), together with 8__ฮฒ__โ€methoxyatractylenolide (4) and atractylenolactam (5). The structures of these compounds were determined on the basis of spectroscopic analyses. The in vitro cytotoxic activities of the isolated metabolites were tested against KB, Daoy, and WiDr cell lines. A biogenetic pathway for these novel compounds was proposed.

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