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New multi-coupling benzylic zinc reagents for the preparation of flexible aromatic compounds

✍ Scribed by Mario Rottländer; Paul Knochel

Book ID
104256560
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
251 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

The benzylic zinc reagents 3a-c bearing a triflate group in o-, m-or p-position are new efficient multi-coupling reagents reacting stepwise with an aryl iodide (Arl-I) and an arylzinc bromide (Ar2ZnBr) in the presence of the appropriate palladium catalyst and the suitable phosphine ligand leading to polyfunctional flexible aromatic products of type 5. This methodology is appropriate for applications in combinatorial chemistry.

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Metallic nickel as a reagent for the cou
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✍ Shin-ichi Inaba; Hideyuki Matsumoto; Reuben D. Rieke 📂 Article 📅 1982 🏛 Elsevier Science 🌐 French ⚖ 142 KB

The oxidative addition of aromatic and benzylic halides to activated metallic nickel occurred under mild conditions to give the corresponding dehalogenative coupled products in good yields. Zero-valent, transition metals in the metallic state generally do not undergo smooth oxidative addition of org