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New MRI method with contrast based on the macromolecular characteristics of tissues

✍ Scribed by Arnon Neufeld; Uzi Eliav; Gil Navon

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
466 KB
Volume
50
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

A new MRI method with a contrast that is derived from the macromolecular composition and spin dynamics in the tissue is described and demonstrated on excised mouse brain and rat spinal cord. In the method, magnetization is selectively excited in the macromolecules by using a double quantum filter and subsequently transferred to water. The new imaging method differs from previous methods that rely on magnetization transfer contrast (MTC) in that it enables a separate and independent control of the effect of the macromolecule characteristics, chemical exchange, and water‐related parameters on the images. Magn Reson Med 50:229–234, 2003. © 2003 Wiley‐Liss, Inc.

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