✦ LIBER ✦

New microtubular agents in pediatric oncology

✍ Scribed by Nita L. Seibel; Gregory H. Reaman

Publisher: Springer US
Year: 1996
Tongue: English
Weight: 588 KB
Volume: 14
Category: Article
ISSN: 0167-6997
DOI: 10.1007/bf00173682

No coin nor oath required. For personal study only.

✦ Synopsis

The taxanes are a new group of anticancer agents with a novel mechanism of action. They promote microtubule assembly and stabilize the microtubules. Paclitaxel (Taxol), the first agent in this group in clinical trials was isolated from the Pacific yew, Taxus brevifolia in 1971. Both in preclinical and clinical studies, paclitaxel and its semisynthetic analog docetaxel exhibit significant antitumor activity. This review will provide an overview of the clinical experience with the group of anti-microtubular agents, the taxanes in pediatric oncology.

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