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New methods for solid phase peptide synthesis of transitionstate analog inhibitors of HIV-1 protease and DPP-IV

✍ Scribed by Jan Piron; Dirk Tourwé


Publisher
Springer Netherlands
Year
1995
Tongue
English
Weight
202 KB
Volume
2
Category
Article
ISSN
1573-3149

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A protocol has been kvelopedjiu rht generation qf hylroxyehyhnine peptide bond isosmes in a poipcr- sqprted synthesis. This has been used to produce the potent HlV-I Protease inhibitor JG345 rqidiy and in good yield. Protease inhibitors have outstanding potential as therapeutic agentst. Recently it