Solid phase synthesis of hydroxyethylami
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Paul F. Alewood; Ross I. Brinkworth; Robert J. Dancer; Bronwyn Garnham; Alun Jon
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Article
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1992
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Elsevier Science
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French
⚖ 274 KB
A protocol has been kvelopedjiu rht generation qf hylroxyehyhnine peptide bond isosmes in a poipcr- sqprted synthesis. This has been used to produce the potent HlV-I Protease inhibitor JG345 rqidiy and in good yield. Protease inhibitors have outstanding potential as therapeutic agentst. Recently it