A novel method for polypeptide synthesis, in which partially protected peptide thioesters are used as building blocks, has been developed. Partially protected peptide thioesters are easily prepared by solid-phase methodology. The thioester moiety is converted to an active ester in the presence of a
New Method of Polypeptide Synthesis
β Scribed by Dipl-Chem. Manfred Mutter; Doz. Dr. Hanspaul Hagenmaier; Prof. Dr. Ernst Bayer
- Publisher
- John Wiley and Sons
- Year
- 1971
- Tongue
- English
- Weight
- 257 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0044-8249
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## Abstract The complete manuscript of this communication appears in: __Angew. Chem. Suppl. 1982__, 1440. DOI:10.1002/anie.198214400
A new optimization method is presented to search for the global minimum-energy conformations of polypeptides. The method combines essential aspects of the build-up procedure and the genetic algorithm, and it introduces the important concept of ''conformational space annealing.'' Instead of consideri