New method for evaluation of hard contact lens materials with regard to cell injury by dynamic contact
✍ Scribed by Iguchi, Ikuo ;Kamiyama, Kenji ;Ohashi, Toshio ;Wang, Xiaoguang ;Imanishi, Jiro
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 570 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0021-9304
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✦ Synopsis
To establish a new method for evaluation of contact lens materials, we studied the porcine endothelial cell injury caused by dynamic contact (rotatory rubbing) with three kinds of hard contact lenses (HCL). The HCLs used were 1) PMMA HCL, 2) oxygen-permeable HCL composed of a graft copolymer of dextran derivative and methylmethacrylate (MMA) (Suncon Mild IITM, 12 Dk), and 3) oxygen-permeable-HCL composed of a copolymer of a monomer containing silicone, a monomer containing fluorine, and MMA (RGPL-A, 216 Dk). Cell injury rates were significantly different among these HCLs (Suncon Mild 11'" < PMMA < RGPL-A) although there were no differences in rotatory rubbing forces.
The smoothness of HCL surface, the qualities of injured cell layers observed by scanning electron microscopy, and the water wettability of HCLs were not correlated with cell injury rate. These results suggest that physicochemical properties of materials other than rotatory rubbing force, smoothness, and water wettability were involved in the cell injury. Our evaluation method for biomaterials that injure the corneal endothelial cells by dynamic contact should be very useful for the development of biomaterials or medical devices, including HCLs and intracardiac and urethral catheters. 0 7996