The synthesis of new tricyclic azaindolic analogs of the hormone melatonin is described. Treatment of 1-(4-bromobutyl)pyrrolo[3,2-b]pyridine derivative with tributyltin hydride and AIBN results in radical cyclisation to give the 6,7,8,9-tetrahydropyrido[2,3-b]indolizine ring system. A new synthetic
✦ LIBER ✦
New melatonin (MT1/MT2) ligands: Design and synthesis of (8,9-dihydro-7H-furo[3,2-f]chromen-1-yl) derivatives
✍ Scribed by Landagaray, Elodie; Ettaoussi, Mohamed; Leclerc, Véronique; Traoré, Balla; Perez, Valérie; Nosjean, Olivier; Boutin, Jean A.; Caignard, Daniel-Henri; Delagrange, Philippe; Berthelot, Pascal; Yous, Saïd
- Book ID
- 125474648
- Publisher
- Elsevier Science
- Year
- 2014
- Tongue
- English
- Weight
- 616 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0968-0896
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