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New mass spectrometric approaches to structural analysis in mixtures

✍ Scribed by Jean-Claude Wolff; Soraya Monté; Neville Haskins; David Bell

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
85 KB
Volume
13
Category
Article
ISSN
0951-4198

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✦ Synopsis

Structural analysis of minor components in mixtures is a vital requirement in the development of any pharmaceutical compound. Mass spectrometry is uniquely able to give this kind of information on the trace amounts of material present as minor impurities in a drug substance. In this study we show that a combination of mass spectrometric analysers with different characteristics is an even more powerful approach with a higher chance of establishing a potential structure. In particular the advent of analysers capable of accurate mass measurement on small amounts of material has enabled structures to be proposed in situations where previously no real conclusions could be made. Copyright 1999 John Wiley & Sons, Ltd.

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