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New Insights into the Mechanism of Alzheimer Amyloid-β Fibrillogenesis Inhibition by N-Methylated Peptides

✍ Scribed by Soto, Patricia; Griffin, Mary A.; Shea, Joan-Emma

Book ID: 119921316
Publisher: Biophysical Society
Year: 2007
Tongue: English
Weight: 864 KB
Volume: 93
Category: Article
ISSN: 0006-3495
DOI: 10.1529/biophysj.107.112086

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## Abstract In this DFT study, a mechanism of the oxidation of methionine (Met) amino acid residue catalyzed by the metal (Cu^2+^, Zn^2+^, and Fe^3+^) bound amyloid beta (Aβ) peptide has been proposed. Based on experimental information, two different mechanisms: (1) stepwise and (2) concerted mecha