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New insights into the inactivation of gastric tumor suppressor RUNX3: The role of H. pylori infection

✍ Scribed by Ying-Hung Nicole Tsang; Acacia Lamb; Dr. Lin-Feng Chen

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 113 KB
Volume: 112
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.22964

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✦ Synopsis

Abstract

Runt‐related transcription factor 3, or RUNX3, is a tumor suppressor in gastric cancer. Inactivation of RUNX3 is causally associated with the genesis of gastric cancer, since RUNX3 is frequently inactivated in gastric cancers by hemizygous deletion, hypermethylation of its promoter, or protein mislocalization. Infection with Helicobacter pylori is the strongest risk factor for the development of gastric cancer. Recent studies have indicated that H. pylori infection plays an important role in the inactivation of RUNX3, and that this inactivation contributes to the pathogenesis of H. pylori. Here we summarize these recent advances and discuss their significances in understanding the initiation and development of gastric cancer. J. Cell. Biochem. 112: 381–386, 2011. © 2010 Wiley‐Liss, Inc.

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