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New insight into structural and stereochemical requirements for selective, high affinity ligands at the dopamine D2 receptor

✍ Scribed by Imhof, R.; Godel, Th.; Burkard, W.P.; Keller, H.H.; Da Prada, M.; Scherschlicht, R.


Book ID
122844600
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
343 KB
Volume
20
Category
Article
ISSN
0197-0186

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2-[(substituted)phenyl]-5-[1-(2-phenylaz
✍ David Bolton; Izzy Boyfield; Martyn C. Coldwell; Michael S. Hadley; Amanda Johns πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 English βš– 192 KB

A series of 2-1(substituted)phenyl]-5-[1-(2-phenylazacycloheptyl)methyl]-lH-pyrroles (8 -15) has been prepared to investigate the effect on affinity and selectivity for the dopamine D 3 receptor of modifying the substituent in the phenyl ring at the 2-position of the pyrrole. Sulfonate 7 and sulfona