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New in-capillary electrophoretic kinase assays to evaluate inhibitors of the PI3k/Akt/mTOR signaling pathway

✍ Scribed by Nehmé, Reine; Nehmé, Hala; Saurat, Thibault; de-Tauzia, Marie-Ludivine; Buron, Frédéric; Lafite, Pierre; Verrelle, Pierre; Chautard, Emmanuel; Morin, Philippe; Routier, Sylvain; Bénédetti, Hélène

Book ID
125341993
Publisher
Springer
Year
2014
Tongue
English
Weight
743 KB
Volume
406
Category
Article
ISSN
1618-2650

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✍ Rommel, Christian; Vanhaesebroeck, Bart; Vogt, Peter K. 📂 Article 📅 2010 🏛 Springer Berlin Heidelberg 🌐 German ⚖ 321 KB

PI3K has become a very intense area of research, with over 2000 publications on PI3K in PubMed for 2009 alone. The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being monitored by many. However, targeted therapies almost inva