New hybrid technique for accurate and reproducible quantitation of dynamic contrast-enhanced MRI data

✍ Scribed by Ka-Loh Li; Alan Jackson

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 478 KB
• Volume: 50
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.10652

✦ Synopsis

Abstract

The accuracy and precision of two major approaches for analyzing dynamic MRI data from the first passage of a Gd‐DTPA contrast bolus are examined, using a Monte Carlo simulation. Method 1 fits the contrast concentration curve of the first pass to a two‐compartment kinetic model to determine the tissue pharmacokinetic parameters. Method 2 decomposes intravascular and interstitial components of the first‐pass curve based on a leakage profile (LP) model. Based on the results of these Monte Carlo simulations, a new “hybrid” method is proposed that combines both analytical approaches to optimize accuracy and precision of estimates of K^trans^, v~e~, and v~p~. The new method was evaluated by computer simulation and used on experimental results from a patient with primary brain tumors. The new method has the potential to provide more accurate quantification of tissue plasma volume and vessel permeability. Magn Reson Med 50:1286–1295, 2003. © 2003 Wiley‐Liss, Inc.