New homodi-and heterotrinuclear metal complexes of Schiff base compartmental ligand: interaction studies of copper complexes with calf thymus DNA

✍ Scribed by Mathur, Suvigya ;Tabassum, Sartaj

• Book ID: 111487902
• Publisher: Walter de Gruyter GmbH
• Year: 2006
• Tongue: English
• Weight: 762 KB
• Volume: 4
• Category: Article
• ISSN: 2391-5420
• DOI: 10.2478/s11532-006-0020-6

✦ Synopsis

The new homodinuclear complexes 1-4 of the type [LM II 2 Cl 2 ], heterotrinuclear complexes 5 and 6 of the type [LM II 2 Sn IV Cl 6 ] where M= Cu II , Mn II , Co II , Ni II and Cu II and Ni II , respectively have been synthesized and characterized by elemental analysis and various spectroscopic techniques. The homodinuclear complexes possess two different environments (N 2 and N 2 O 2 donor sets) for holding the metal ions. The metal ion in N 2 set exhibits square planar geometry with two chloride ions in the inner sphere but rhombic structure is found in tetradentate N 2 O 2 Schiff base cavity while in heterotrinuclear complexes Sn IV atom is in the octahedral environment. The interaction of complexes 1 and 5 with calf thymus DNA was carried out by absorption spectroscopy and cyclic voltammetry. The intrinsic binding constants (K b ) of complex 1 and 5 were determined as 3.2 × 10 3 M -1 and 9.6 × 10 3 M -1 , respectively suggesting that complex 5 binds more strongly to CT-DNA than complex 1. Fluorescence studies along with viscosity measurements have also been checked to authenticate the binding of metal complexes with DNA.