New histamine and histidine analogs via transformations of the 2-trifluoromethyl group
โ Scribed by Kimoto, Hiroshi; Cohen, Louis A.
- Book ID
- 118032362
- Publisher
- American Chemical Society
- Year
- 1980
- Tongue
- English
- Weight
- 755 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0022-3263
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The reactions of potassium Rf-amide [R, = tris(trifluor0methyl)phenyl] (2) with PCl,, AsC13, and GeC1, 'dioxane yield new four-membered inorganic heterocycles [R,NPCl], (3), [RfNAsC1], (4), and [RfNGeI2 (5), respectively. On the other hand, the reaction of Rf-amide 2 with two equivalents of RfPCla l
Treatment of 2a, b with LiAIH 4 gave the [61 and [7]metacyclophanols 4 and8 in good yields. The reactions of 4 and 8 with MeSO2CI in the presence of Et3N in CH2CI 2 rapidly proceeded to give the corresponding strained tricyclic ethers 6 and 10 via an intramolecular version of the SN2 reaction. This