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New, Highly Active Nonbenzoquinone Geldanamycin Derivatives by Using Mutasynthesis

✍ Scribed by Simone Eichner; Heinz G. Floss; Florenz Sasse; Andreas Kirschning


Book ID
101820718
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
210 KB
Volume
10
Category
Article
ISSN
1439-4227

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✦ Synopsis


Supporting information for this article is available on the WWW under http://dx.doi.org/10.1002/cbic.200900246. Scheme 1. Principal biosynthetic pathway of geldanamycin (1) (ACP = acyl carrier protein of last PKS-module) and structures of reblastatin (2) and 3amino-5-hydroxybenzoic acid (AHBA, 3).


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