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New hetero-oligomeric peptide nucleic acids with improved binding properties to complementary DNA

✍ Scribed by Stephan Jordan; Christoph Schwemler; Winfried Kosch; Axel Kretschmer; Udo Stropp; Eckhardt Schwenner; Burkhard Mielke

Book ID: 104364897
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 272 KB
Volume: 7
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(97)00085-1

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✦ Synopsis

Hetero-oligomeric PNAs consisting of new monomeric building blocks and various amounts of N-(2-aminoethyl) glycine have been synthesized by solid-phase chemistry. Some of these new compounds show stronger binding to complementary DNA than the original PNAs, and are consequently very interesting candidates as antisense compounds for applications in therapy and in diagnostics.

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