New grade-related prognostic variable for rectal cancer

✍ Scribed by G. Gagliardi; K. A. Stepniewska; M. J. Hershman; P. R. Hawley; Dr. I. C. Talbot

• Book ID: 101749612
• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 471 KB
• Volume: 82
• Category: Article
• ISSN: 0007-1323
• DOI: 10.1002/bjs.1800820508

✦ Synopsis

Abstract
The effect of microacinar growth patterns on survival after radical surgery for rectal cancer was assessed in 138 consecutive patients. All had Dukes and Jass staging and a median follow-up of 95 (range 11–180) months. Tumour acini were classified according to size (microacinar, 28; macroacinar, 110). Patients with microacinar tumours had a significantly reduced 5-year survival rate compared with those with macroacinar lesions (43 and 68 per cent respectively, P = 0.004). When examined in the presence of other histological factors, acinar size had independent prognostic value (relative risk 2.37, P = 0.006). This was true even when the Dukes and Jass classifications were included in the model (relative risk 2.08, P = 0.02 and 1.95, P = 0.03 respectively). Histological classification of rectal tumours into microacinar and macroacinar types adds prognostic value to the Dukes and Jass classifications and may be a more objective criterion than conventional histological grading.