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New genes in alkaloid metabolism and transport

✍ Scribed by Takashi Hashimoto; Yasuyuki Yamada

Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
119 KB
Volume
14
Category
Article
ISSN
0958-1669

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✦ Synopsis

The biosynthetic pathway of plant alkaloids is composed of several distinct enzymes of varying substrate specificities. Homology-based cloning of candidate genes and their subsequent functional testing in heterologous expression systems are accelerating the pace at which the gene catalogues of alkaloid biosynthesis are expanding. Availability of diverse genes involved in the biosynthesis, catabolism, transport, and regulation of pharmaceutically important alkaloids should steadily advance our molecular understanding of alkaloid biology and will enable us to devise more rational strategies for metabolic engineering.

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