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New geiparvarin analogues from 7-(2-oxoethoxy)coumarins as efficient in vitro antitumoral agents

✍ Scribed by Stefano Chimichi; Marco Boccalini; Barbara Cosimelli; Giampietro Viola; Daniela Vedaldi; Francesco Dall'Acqua

Book ID: 104252051
Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 184 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)01798-7

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✦ Synopsis

A new class of compounds analogues of geiparvarin is described: aldolic condensation of 3(2H)-furanones and 7-(2-oxoethoxy)coumarins followed by a very efficient dehydration protocol led to the title compounds which show good antitumoral activity against several human cell lines.

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