New furostanol saponins from Allium ascalonicum L.

✍ Scribed by Li-Ping Kang; Zhi-Jun Liu; Lei Zhang; Da-Wei Tan; Yang Zhao; Yu Zhao; He-Bing Chen; Bai-Ping Ma

• Book ID: 102950993
• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 542 KB
• Volume: 45
• Category: Article
• ISSN: 0749-1581
• DOI: 10.1002/mrc.2037

✦ Synopsis

Abstract

An analysis of the polar extracts from Allium ascalonicum L. led to the isolation of two new furostanol saponins (compound 1 and 2) and two known furostanol saponins (compound 3 and 4). On the basis of 1D and 2D NMR (including ^1^H, ^13^C NMR, ^1^H^1^H COSY, HSQC, TOCSY, HMBC, and NOESY), FAB‐MS spectrometry, and chemical methods, their structures were elucidated as (25__R__)‐26‐O‐β‐D‐glucopyranosyl‐22‐hydroxy‐5α‐furost‐2‐one‐3β, 5, 6β, 26‐tetraol‐3‐O‐α‐L‐rhamnopyranosyl‐(1→2)‐β‐D‐glucopyranoside (ascalonicoside C, 1), (25__R__)‐26‐O‐β‐D‐glucopyranosyl‐22‐methoxy‐5α‐furost‐2‐one‐3β, 5, 6β, 26‐tetraol‐ 3‐O‐α‐L‐rhamnopyranosyl‐(1→2)‐β‐D‐glucopyranoside (ascalonicoside D, 2), (25__R__)‐26‐O‐β‐D‐glucopyranosyl‐22‐hydroxy‐5‐ene‐furostan‐3β, 26‐diol‐3‐O‐α‐L‐rhamnopyranosyl‐(1→4)‐α‐L‐rhamnopyranosyl‐(1→4)‐[α‐L‐rhamnopyranosyl‐(1→2)]‐β‐D‐glucopyranoside (dichotomin, 3), and (25__R__)‐26‐O‐β‐D‐glucopyranosyl‐22‐hydroxy‐5‐ene‐furostan‐3β, 26‐diol‐3‐O‐α‐L‐rhamnopyranosyl‐(1→2)‐[α‐L‐arabinofuranosyl‐(1→4)]‐β‐D‐ glucopyranoside (parisaponin I, 4). Copyright © 2007 John Wiley & Sons, Ltd.