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New fluorinating reagents - I. The first enantioselective fluorination reaction

โœ Scribed by Edmond Differding; Robert W. Lang


Publisher
Elsevier Science
Year
1988
Tongue
French
Weight
209 KB
Volume
29
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


Crystalline, optically pure N-fluoro sultams (-)-3 and (+)-5 are the first examples of enan-tioselective fluorinating reagents. Thus unprecedented enantiomeric excesses up to 70%


๐Ÿ“œ SIMILAR VOLUMES


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A new Si-induced Vilsmeier-type formylation of F-containing organozinc reagents is described. This two-step process via the isolable intermediate 10 Seems to be quite general for the synthesis of anhydrous polyhalogenated aldehydes. Various polyfluorinated hydrocarbons are excellent starting materi

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Syntheses of fluoro compounds by nucleophilic substitution of bromides or methanesulfonates using Et3fi.2HF as the reagent are reported. The formation of undesired elimination side products IS limited. The synthesis of this new fluorinating reagent is also reported. Many methods have been developed