New findings in the behavioral profile of young fraX females

✍ Scribed by Borghgraef, Martine ;Umans, Stijn ;Steyaert, Jean ;Legius, Eric ;Fryns, Jean-Pierre

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 393 KB
• Volume: 64
• Category: Article
• ISSN: 0148-7299
• DOI: 10.1002/(sici)1096-8628(19960809)64:2<346::aid-ajmg22>3.0.co;2-e

✦ Synopsis

Nine girls, with a 50% risk to be carrier of the FMR-1 gene and who attended normal school and did not have a mentally retarded fraX relative, were selected to exclude influences of external factors. These subjects were submitted to an extensive neurocognitive and psychiatric evaluation before molecular analysis of their FMR-1 status was done to obtain completely unbiased results. The findings of this study suggest that differentiation according to the FMR-1 status may be more significant at the neurocognitive level than at the behavioral level and support the hypothesis that behavioral problems are more influenced by external factors than by the FMR-1 carrier state.