New features of the intramolecular Diels Alder route to hydroisoindoles

✍ Scribed by John M. Mellor; Alison M. Wagland

• Publisher: Elsevier Science
• Year: 1987
• Tongue: French
• Weight: 215 KB
• Volume: 28
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)96724-8

✦ Synopsis

Regio-and stereo-controlled routes to functionalised hydroisoindoles have been developed by reaction of aminodienes with unsaturated anhydrides or acid chlorides and subsequent elaboration of the Diels Alder adducts. A recent publication' notes the limited use of the intramolecular Diels Alder (IMDA) reaction in the construction of nitrogen heterocycles, and in particular, hydroisoindoles, and describes improved stereoselective routes to such targets. Such limitations contrast with the more advanced use of the IMDA reaction in the construction of carbocycles 2 , or