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New evidence for roles of antinucleosome antibodies in systemic lupus erythematosus

✍ Scribed by De-Guang Wang; Li Hao; Hai-Feng Pan; Dong-Qing Ye


Publisher
Springer
Year
2011
Tongue
English
Weight
63 KB
Volume
31
Category
Article
ISSN
0770-3198

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## Abstract ## Objective To identify the prevalence of serologically active clinically quiescent (SACQ) patients in a cohort of 290 patients with systemic lupus erythematosus (SLE). We investigated if the presence of anti–double‐stranded DNA (anti‐dsDNA) or antinucleosome (anti‐NCS) antibodies dur

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Antibody a c t i v i t y t o various histones was examined i n a s o l i d phase radioimmunoassay. More than one h a l f o f the sera from systemic lupus erythematosus (SLE) p a t i e n t s had IgM a c t i v i t y t o t o t a l histones, and a s l i g h t l y lower frequency was observed f o r IgG a