## Abstract Five new eremophilane‐type sesquiterpenes, 3__β__‐(acetyloxy)‐7‐hydroxynoreremophila‐6,9‐dien‐8‐one (**1**), 8__β__‐hydroxy‐2‐dehydroxyliguhodgsonal (**2**), 3__β__‐(acetyloxy)‐11‐methoxy‐8‐oxoeremophila‐6,9‐dien‐12‐oic acid (**3**), 3__β__‐(acetyloxy)‐11‐(2′‐methylbutanoyloxy)‐8‐oxoere
New Eremophilane Sesquiterpenes from Ligularia japonica
✍ Scribed by Ji-Qing Xu; Li-Hong Hu
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- German
- Weight
- 159 KB
- Volume
- 92
- Category
- Article
- ISSN
- 0018-019X
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
magnified image
Four new eremophilane‐type sesquiterpenes, 3__β__‐(acetyloxy)‐6__β__‐(2‐methylbutanoyloxy)‐10__β__‐hydroxyeremophil‐7(11)‐en‐12,8__α__‐olide (1), 3__β__‐(acetyloxy)‐6__α__,7__α__‐epoxy‐11‐noreremophil‐9(10)‐ene‐8,11‐dione (2), 3__β__‐hydroxy‐11‐noreremophila‐6(7),9(10)‐diene‐8,11‐dione (3), and 3__β__‐(3‐methylbutanoyloxy)‐11‐noroxoeremophila‐6(7),9(10)‐diene‐8,11‐dione (4) were isolated from roots of Ligularia japonica. The structures of the new compounds were elucidated through spectral studies including HR‐EI‐MS, IR, and NMR data.
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Introduction. -The genus Ligularia has been taxonomically placed in the Compositae (tribe Senecioneae), and comprises ca. 100 species in China [1]. Some 27 species in this genus have long been used as folk remedies for their antibiotic, antiphlogistic, and antitumor activities [2]. Ligularia plants
## Abstract A novel eremophilane dimer, named as fischelactone, and a new sesquiterpene lactam, eremophila‐1(10),7(11),8‐triene‐12,8‐lactam, along with ten known compounds, were isolated from the roots of __Ligularia fischeri.__ Their structures were established by means of spectroscopic analyses (