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New entry to syn-β-hydroxy-α-amino acids

✍ Scribed by Mosahiro Hirama; Hideaki Hioki; Shô Itô


Book ID
103399926
Publisher
Elsevier Science
Year
1988
Tongue
French
Weight
289 KB
Volume
29
Category
Article
ISSN
0040-4039

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The diastereoselective synthesis of syn-a-alkyl a-hydroxy 13-amino acids 4a-h was easily accomplished by reaction of the sodium dianion of the corresponding anti a-alky113-benzoylamino acid methyl esters with iodine. The intermediate a-iodo derivatives spontaneously afforded c/s-oxazolines which, up