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New ent-Abietanoids from Isodon rubescens

✍ Scribed by Quan-Bin Han; Rong-Tao Li; Ji-Xia Zhang; Han-Dong Sun

Publisher: John Wiley and Sons
Year: 2004
Tongue: German
Weight: 147 KB
Volume: 87
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.200490072

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✦ Synopsis

Abstract

Six new ent‐abietane diterpenoids, rubescensins I–M (1–5) and P (6), along with two related acetonide derivatives (7 and 8), were isolated from Isodon rubescens. Their structures were elucidated by detailed spectroscopic analysis. Compound 5 is the first N‐containing diterpenoid from the genus Isodon, exhibiting notable cytotoxicity against human tumor K562 cells.

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