New electrical properties of neurons induced by a homeoprotein

✍ Scribed by Aisemberg, Gabriel O. ;Gershon, Timothy R. ;Macagno, Eduardo R.

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 303 KB
• Volume: 33
• Category: Article
• ISSN: 0022-3034
• DOI: 10.1002/(sici)1097-4695(199707)33:1<11::aid-neu2>3.0.co;2-g

✦ Synopsis

To explore possible neurogenic mRNA injection did not affect the resting potential, functions of the genes of the Hox/HOM complexes, input resistance, or axonal morphology of the transwe injected the mRNA from the leech homeobox genes Lox1 and Lox4 into adult neurons that normally do formed APs, raising the possibility that it acts via the not express them. The ectopic expression of Lox1 inmodification of voltage-dependent ion channels. Thus, duced a specific transformation in the electrical propa specific homeobox gene can transform key neuronal erties of certain identified neurons: action potential characteristics in a cell-specific manner. We may thus amplitude increased about threefold after the injecadd electrophysiologic properties to other aspects of tions. This effect of Lox1 expression was restricted, neuronal identity determined by homeobox gene among cell types examined, to the anterior pagoda expression. ᭧ 1997 John Wiley & Sons, Inc. J Neurobiol 33: 11- neurons (APs) and the nut neurons. This effect was 17, 1997 also restricted to Lox1 ectopic expression; the action Keywords: neuron; homeobox; leech; action potential; potentials of APs and nut neurons were not enlarged gene expression when the mRNAs of either Lox4, another leech Hox/