I will try to summarize the evidence that immunosuppressive drugs may be useful in the therapy of connective tissue diseases. In order to simplify my task I will confine my discussion to two drugs-cyclophosphamide and azathioprine-because these are the two about which there is sufficient controlled
New drugs in rheumatic disease
β Scribed by Glenn M. Clark
- Publisher
- John Wiley and Sons
- Year
- 1962
- Tongue
- English
- Weight
- 284 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
β¦ Synopsis
RECENT YEARS there has been an increasing trend toward the rapid I introduction of "new and more potent" therapeutic agents in the field of rheumatology. Many of these have no proven qualitative differences on comparison with the "newer and more potent agents" of other years. Before joining the rush to accept any of these agents, it seems logical that the answer to at least one of the following questions should be yes:
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Is there evidence that the new drug will accomplish a therapeutic aim more effectively than a drug with which we have had more experience?
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When the drug is given in a dosage producing an equal therapeutic effect, is the risk of producing undesirable effects or of poisoning the patient less than that with alder drugs?
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Is there some advantage in cost or convenience of administration which may make the new preparation desirable?
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