New DNA polymorphisms of human MMH/OGG1 gene: Prevalence of one polymorphism among lung-adenocarcinoma patients in Japanese
✍ Scribed by Toshimitsu Ishida; Rieko Takashima; Masashi Fukayama; Chikuma Hamada; Yoshitaka Hippo; Takeshi Fujii; Sachiko Moriyama; Chikako Matsuba; Yutaka Nakahori; Hiroyuki Morita; Yoshio Yazaki; Tatsuhiko Kodama; Susumu Nishimura; Hiroyuki Aburatani
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- French
- Weight
- 78 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
✦ Synopsis
MMH/OGG1 is an 8-hydroxyguanine-specific DNA glycosylase/AP-lyase, one of the mutator enzymes for the excision repair of 8-hydroxyguanine. DNA polymorphisms in human MMH/OGG1 gene were newly identified and analyzed to examine a possible association with lung-cancer risk by a population-based study. Polymorphic allele 3 in hMMH/OGG1 exon 1 was significantly prevalent among Japanese patients with adenocarcinoma of the lung [odds ratio (OR): 3.152, 95% confidence interval (CI): 1.266-7.845], indicating that the excision repair of 8-hydroxyguanine may play a role in predisposition to lung cancer. Int.