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New diterpene isocyanides from a sponge

✍ Scribed by R. Kazlauskas; P.T. Murphy; R.J. Wells; J.F. Blount

Publisher
Elsevier Science
Year
1980
Tongue
French
Weight
259 KB
Volume
21
Category
Article
ISSN
0040-4039

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✦ Synopsis

Sumnary: Six new dlterpene isocyanldes have been isolated from a sponge (Adocla sp.). Their structures support the biosynthetic suggestion for the formation of diisocaociane reported from the same sponge. We have previously reported the isolation of diisocyanoadociane (1) from a species of the sponge genus Adoclal and suggested that this unique tetracycllc diterpene could be formally derived from a suitable 'regular' diterpene precursor by means of a single methyl shift as shown in (2). The recent isolation of 8,15-diisocyano-11(2D)-amphllectene (3) from the sponge Hymeniacidon amphilecta2 3 supported this biosynthetic suggestion and prompts us to report the structures of six new tri-and tetracycllc lsocyanides which co-occur with (1).

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## Sponges of the orders Dictyoceratida and Dendroceratida, the spiculeless horny sponges, have produced a plethora of terpenoid metabolites' including a new diterpenoid ring system of which isoagathalactone (11, from certain collections of the Dictyoceratid sponge Spongia officinalis, was the fir