New Developments in Stereoselective Palladium-Catalyzed Allylic Alkylations of Preformed Enolates
β Scribed by Manfred Braun; Thorsten Meier
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 8 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract Lithium and magnesium enolates of cyclohexanone undergo palladiumβcatalyzed allylic alkylations under mild conditions. Diastereoselectivity and enantioselectivity are observed when the diphenylβ and dimethylβsubstituted allylic substrates **1a** and **1b** are reacted with cyclohexanone
## Abstract Palladiumβcatalyzed asymmetric allylic alkylation of nonstabilized ketone enolates to generate quaternary centers has been achieved in excellent yield and enantioselectivity. Optimized conditions consist of performing the reaction in the presence of two equivalents of LDA as base, one e
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