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New derivatives of trans 2-phenoxycyclohexanol with potential local anesthetic activity

โœ Scribed by Patrick Depreux; Annie Marcincal-Lefebvre; Claude Brunet


Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
280 KB
Volume
22
Category
Article
ISSN
0223-5234

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โœ H. Jack Adams; George H. Kronberg; Bertil H. Takman ๐Ÿ“‚ Article ๐Ÿ“… 1972 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 286 KB

This paper is concerned with the local anesthetic activity and acute toxicity of (+~)-2-(N-ethylpropylamino)-2',6'-butyroxylidide (I). Testing in rat sciatic nerve blocks and guinea pig intradermal wheals showed that the compound has rapid onset, excellent frequency, and long durations of block. The