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New cytotoxic sesquiterpenoid nitrobenzoyl esters from a marine isolate of the fungus Aspergillus versicolor

โœ Scribed by Gilbert N. Belofsky; Paul R. Jensen; Matthew K. Renner; William Fenical

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
577 KB
Volume
54
Category
Article
ISSN
0040-4020

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โœฆ Synopsis

Four new sesquiterpenoid nitrobenzoyl esters (1-4) have been isolated from organic extracts of the culture broth and myeelia of Aspergillus versicolor, a fungus isolated from the surface of the Caribbean green alga Penicillus capitatus. The structures of the four compounds were determined through extensive analysis of IH NMR, ~3C NMR, HMQC, and HMBC data. 9~t,14-Dihydroxy-61]-pnitrobenzoylcinnamolide (1) displayed significant cytotoxicity against HCT-I16 human colon carcinoma cells in vitro and exhibited moderately selective cytotoxicity toward a panel of renal tumor cell lines.

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