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New Cytotoxic Prostanoids from Taiwanese Soft Coral Clavularia viridis

โœ Scribed by Ya-Ching Shen; Kuang-Liung Lo; Jiun-Yang Chang; Yun-Sheng Lin; Khongorzul Mendbayar; Yao-Haur Kuo; Yu-Chi Lin

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
347 KB
Volume
7
Category
Article
ISSN
1612-1872

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โœฆ Synopsis

Abstract

Chemical investigation of the AcOEt/MeOH extract of Clavularia viridis collected in Taiwan has afforded four new prostanoids, named claviridins Aโ€“D (1โ€“4, resp.). The structures of compounds 1โ€“4 were determined on the basis of 1Dโ€ and 2Dโ€NMR techniques, including COSY, HMQC, HMBC, and NOESY experiments. Pharmacological studies revealed that compounds 1โ€“4 exhibited potent cytotoxicity against human cancer cells.

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