New Cytotoxic Metabolites from a Deep-Sea-Derived Fungus, Phialocephala sp., Strain FL30r

✍ Scribed by De-Hai Li; Sheng-Xin Cai; Tian-Jiao Zhu; Feng-Ping Wang; Xiang Xiao; Qian-Qun Gu

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 162 KB
• Volume: 8
• Category: Article
• ISSN: 1612-1872
• DOI: 10.1002/cbdv.201000134

✦ Synopsis

Abstract

Two new sorbicillinoids, 1 and 2, together with a novel benzofuranone derivative named phialofurone (3), were isolated from a deep‐sea sediment‐derived fungus, Phialocephala sp__.__ Their structures were established on the basis of spectroscopic data. All compounds displayed cytotoxic effects against P388 (IC~50~ values of 11.5±1.4, 0.1±0.1, and 0.2±0.01 μM, resp.) and K562 (IC~50~ values of 22.9±0.8, 4.8±0.3 and 22.4±0.9 μM, resp.) cell lines.