✦ LIBER ✦
New Cyanopeptide-Derived Low Molecular Weight Inhibitors of trypsin-like Serine Proteases
✍ Scribed by Gregor Radau; Sonja Schermuly; Alexandra Fritsche
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 171 KB
- Volume
- 336
- Category
- Article
- ISSN
- 0365-6233
No coin nor oath required. For personal study only.
✦ Synopsis
This paper deals with the design, syntheses, and inhibition tests of new low molecular weight thrombin inhibitors utilizing cyanopeptides, the secondary metabolites of cyanobacteria with interesting biological activities, as new lead structures. Starting with aeruginosin 98-B (1) as a lead structure, we have developed and synthesised new, selective acting inhibitors of serine proteases (RA-1005 and RA-1009, which are suitable targets for further structure-activity studies.