In long-term clinical trials, interim analyses are planned to reduce the number of patients needed. To meet this issue in a practical way, group sequential designs are used. Most of these trials are conducted with the objective of demonstrating di!erences in e$cacy of treatments, for example, to sho
โฆ LIBER โฆ
New critical values for the average equivalence test
โ Scribed by E.E.M van Berkum; H.N Linssen; D.A Overdijk
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 614 KB
- Volume
- 121
- Category
- Article
- ISSN
- 0378-3758
No coin nor oath required. For personal study only.
โฆ Synopsis
Consider a sample of size n ยฟ 2 from a normal distribution with mean . In the average equivalence test the hypothesis | | ยฟ is tested versus | | 6 . In this paper the critical value 0 ยก t( ; s; n) ยก of the average equivalence test is discussed, i.e. the hypothesis | | ยฟ is rejected if the observed sample mean x satisรฟes |x| ยก t( ; s; n). Here s is the observed sample standard deviation and 0:5 ยก ยก 1 the conรฟdence level of the average equivalence test.
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