New compounds: 5-chloro-2-(3-chloro-2-hydroxypropoxy)-benzhydrylamine and Related Compounds
✍ Scribed by Heino A. Luts; D. Yamashiro
- Publisher
- John Wiley and Sons
- Year
- 1968
- Tongue
- English
- Weight
- 130 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0022-3549
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## Abstract Eight new 2‐methyl‐4(3__H__)‐quinazolinones **(8a‐8d, 9c, 9d, 10c, 10d)** with one or two chlorine atoms in the benzene ring and a 5‐methyl‐1,3‐thiazol‐2‐yl, 4‐methyl‐1,3‐thiazol‐2‐yl, and 5‐ethyl‐1,3,4‐thiadiazol‐2‐yl substituent in position 3 of the heterocyclic ring were synthesized
In this study, we have explored the prevention of gastric side effects such as gastric lesions and bleeding while maintaining the high analgesic and anti-inflammatory activities by the derivatization of the carboxylate moiety into amides in [5-chloro-6-(2-chloro/fluorobenzoyl)-2-benzoxazolinone-3-yl