New complexities in helper T cell fate determination and the implications for autoimmune diseases
✍ Scribed by Hiroaki Takatori; Yuka Kanno; Zhi Chen; John J. O’Shea
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 288 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1439-7595
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract TCR degeneracy may facilitate self‐reactive T cell activation and the initiation of an autoimmune response in multiple sclerosis (MS). MHC class II alleles of the DR2 haplotype DR2a (DRB5\*0101) and DR2b (DRB1\*1501) are associated with an increased risk for MS in Caucasian populations.
Analysis of the T cell repertoire for myelin basic protein in thymus-grafted and other types of chimera: evidence that major histocompatibility complex molecules on accessory cells rather than T cell specificity mainly regulate susceptibility to autoimmune encephalomyelitis\* Experimental autoimmune