New Clerodane Diterpenoids from Casearia membranacea

✍ Scribed by Ya-Ching Shen; Cheng Lin Lee; Ashraf Taha Khalil; Yuan-Bin Cheng; Ching-Te Chien; Yao-Haur Kuo

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: German
• Weight: 114 KB
• Volume: 88
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200490297

✦ Synopsis

Abstract

Bioassay‐guided fractionation of an AcOEt extract of Casearia membranacea resulted in the isolation of six new clerodane diterpenes, caseamembrins G–L (1–6). The structures of the new compounds, including their relative configurations, were established by an extensive study of their spectral data, especially 2D NMR. The cytotoxic activities of the isolated diterpenes against human oral epidermoid (KB), cervical epitheloid (Hela), and liver (Hep59T/VGH) carcinoma cell lines were investigated.