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New classes of selective D-1 dopamine receptor antagonist provide further evidence for two directions of D-1:D-2 interaction

โœ Scribed by Daly, Siobhan A.; Waddington, John L.

Book ID
123519531
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
427 KB
Volume
20
Category
Article
ISSN
0197-0186

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Further evidence for two directions of D
Further evidence for two directions of D-1:D-2 dopamine receptor interaction revealed concurrently in distinct elements of typical and atypical behaviour: studies with the new enantioselective D-2 agonist LY 163502
โœ Angela M. Murray; John L. Waddington ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› Springer ๐ŸŒ English โš– 690 KB

The new, extremely potent and enantioselective D-2 agonist LY 163502 failed to induce compulsive stereotyped behaviour. Very low doses (3-6 gg/kg) inhibited spontaneous sniffing and locomotion, while higher doses (12-50 gg/kg)induced episodes of non-stereotyped sniffing and chewing; these actions sh