New chiral stationary phases based on (R)-1-naphthylethylamine bound to 2,4,5,6-tetrachloro-1,3-dicyanobenzene

Preparation and evaluation of chiral sta

Preparation and evaluation of chiral stationary phases based on N,N-2,4-(or 4,6)-disubstituted 4,5-(or 2,5)-dichloro-1,3-dicyanobenzene

✍ Darko Kontrec; Vladimir Vinković; Vitomir Šunjić 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 192 KB 👁 1 views

Regioselective functionalization of 2,4,5,6-tetrachloro-1, 3-dicyanobenzene (TCDCB) by nucleophilic substitution of the chlorine at C(4) with L-Ala, L-Phe or L-Pro, followed by amide-bond formation to lipophilic amines containing strong pi-donor group, and by final introduction of the spacer 3-amino