New Chiral Oxazoline-Phosphite Ligands for the Enantioselective Copper-Catalyzed 1,4-Addition of Organozinc Reagents to Enones
β Scribed by Iris H Escher; Andreas Pfaltz
- Book ID
- 108370783
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 245 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0040-4020
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π SIMILAR VOLUMES
Enantioselective Copper-Catalyzed 1,4-Addition of Organozinc Reagents to Enones Using Chiral Oxazoline-Phosphite Ligands. -The enantioselective 1,4-addition of organozinc reagents to Ξ±,Ξ²-unsaturated ketones in the presence of chiral P,N-ligands (I) with a binaphthyl phosphite group and an oxazoline
The copper catalyzed conjugate addition of n-butyl Grignard to enones in the presence of chiral ferrocenyl phosphine oxazoline ligands has been studied and found to provide useful levels of asymmetric induction. A comparison of the ferrocene derived ligands 3 and 6 with the corresponding phenyl deri