✦ LIBER ✦
New Chiral Hosts Derived from Dimeric Tartaric Acid: Efficient Optical Resolution of Aliphatic Alcohols by Inclusion Complexation
✍ Scribed by Koichi Tanaka; Shinji Honke; Zofia Urbanczyk-Lipkowska; Fumio Toda
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 446 KB
- Volume
- 2000
- Category
- Article
- ISSN
- 1434-193X
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✦ Synopsis
The novel, chiral, host compounds 8 and 9 were derived from tartaric acid. Inclusion complexation with these host compounds permitted highly efficient resolution of some aliphatic alcohols (10-13). The symmetrical dimer host compound 8 is effective for optical resolution of alcohols 10, 12, and 13 by a combination of enantioselective inclusion com-
Results and Discussion
Heating a solution of (ϩ)-diethyl tartrate and 0.5 molar equivalents of cyclohexane-1,4-dione in toluene at reflux